Multi-population genome-wide association meta-analysis in pediatric steroid-sensitive nephrotic syndrome

Steroid-sensitive nephrotic syndrome (SSNS) is the most common glomerular disease in children. The exact mechanisms underlying pediatric SSNS (pSSNS) remain elusive and may be heterogeneous. Nevertheless, numerous observations implicate immune dysregulation, including the triggering of flares by allergy or infections, the response to steroids/immunosuppressants, the immediate post-transplant recurrence in some cases, the unique description of remission of post-transplant nephrotic syndrome (NS) after kidney graft explantation followed by retransplantation to a non-nephrotic recipient, and abnormalities in T and B lymphocyte function.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: nephrology digest Source Type: research