Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

CONCLUSIONS: SPHK2 expression and its activation of the reversible histone H3K9 acetylation in human pulmonary artery smooth muscle cell represent new therapeutic targets that could mitigate PH vascular remodeling.PMID:37698017 | DOI:10.1161/CIRCRESAHA.123.322740

Source: Circulation Research - September 12, 2023 Category: Cardiology Authors: A Dushani C U Ranasinghe Maggie Holohan Kalyn M Borger Deborah L Donahue Rafael D Kuc Martin Gerig Andrew Kim Victoria A Ploplis Francis J Castellino Margaret A Schwarz Source Type: research