Propofol suppresses OGD/R-induced ferroptosis in neurons by inhibiting the HIF-1 α/YTHDF1/BECN1 axis

CONCLUSIONS: Our study revealed that the HIF-1α/YTHDF1/BECN1 axis in OGD/R-treated HT22 cells promotes ferroptosis, and administration of propofol can inhibit this axis to avoid cell death. This study provides a novel insight for the neuroprotective function of propofol.PMID:37614036 | DOI:10.1080/02699052.2023.2237881

Source: Brain Injury - August 24, 2023 Category: Neurology Authors: Hongyan Ma Dongxue Ye Yuqing Liu Pei Wu Lu Yu Libo Guo Yang Gao Ying Liu Haiyan Yan Jinghui Shi Source Type: research