Withaferin A suppressed hepatocellular carcinoma progression through inducing IGF2BP3/FOXO1/JAK2/STAT3 pathway-mediated ROS production

Conclusions: WA-induced ROS inhibited HCC cell growth and migration through the inhibition of IGF2BP3 to deactivate JAK2/STAT3 signaling, resulting in increased FOXO1 expression to further stimulate ROS production and inhibit JAK2/STAT3 signaling.PMID:37671837 | DOI:10.1080/08923973.2023.2247552

Source: Immunopharmacology and Immunotoxicology - September 6, 2023 Category: Allergy & Immunology Authors: Jinhai Li Mengchen Ge Pengcheng Deng Xinquan Wu Longqing Shi Yu Yang Source Type: research