Effects of sex hormones on vascular reactivity in boys with hypospadias

CONCLUSION: In healthy boys, testosterone and 17β-estradiol promote a vasoconstrictor phenotype whereas in boys with hypospadias, these sex hormones reduce vasoconstriction, with androgens promoting vasorelaxation. Differences in baseline artery function may therefore be sex hormone independent and the impact of early-life variations in androgen exposure on vascular function needs further study.PMID:37672642 | DOI:10.1210/clinem/dgad525

Source: The Journal of Clinical Endocrinology and Metabolism - September 6, 2023 Category: Endocrinology Authors: Angela K Lucas-Herald Augusto C Montezano Rheure Alves-Lopes Laura Haddow Stuart O'Toole Martyn Flett Boma Lee S Basith Amjad Mairi Steven Jane McNeilly Katriona Brooksbank Rhian M Touyz S Faisal Ahmed Source Type: research