Dosimetric Validation for Prospective Clinical Trial of GRID Collimator-Based Spatially Fractionated Radiation Therapy: Dose Metrics Consistency and Heterogeneous Pattern Reproducibility

CONCLUSION: GRID collimator based SFRT delivers a consistent heterogeneity dose distribution and high dose core density across bulky tumor plans. The inter-plan reproducibility and simplicity of GRID therapy may be useful for certain clinical indications and inter-institutional clinical trial design, and its heterogeneity metrics may help guide MLC-based SFRT planning to achieve similar or further optimized dose distributions.PMID:37660738 | DOI:10.1016/j.ijrobp.2023.08.061

Source: Physics in Medicine and Biology - September 3, 2023 Category: Physics Authors: Hualin Zhang Lijun Ma Andrew Lim Jason Ye Lauren Lukas Heng Li Nina A Mayr Eric Lin Chang Source Type: research