Diagnostic value of MRI radiomics in differentiating high ‑grade glioma from low‑grade glioma: A meta‑analysis

Oncol Lett. 2023 Aug 23;26(4):436. doi: 10.3892/ol.2023.14023. eCollection 2023 Oct.ABSTRACTNo clear conclusions have yet been reached regarding the accuracy of magnetic resonance imaging (MRI) radiomics in distinguishing high-grade glioma (HGG) from low-grade glioma (LGG). In the present study, a meta-analysis was conducted to determine the diagnostic value of MRI radiomics in differentiating between HGG and LGG, in order to guide their clinical diagnosis. PubMed, Embase and the Cochrane Library databases were searched up to November 2022. The search included studies in which true positive, false positive, true negative and false negative values for the differentiation of HGG from LGG were reported or could be calculated by retrograde extrapolation. Duplicate publications, research without full text, studies with incomplete information or unextractable data, animal studies, reviews and systematic reviews were excluded. STATA 15.1 was used to analyze the data. The meta-analysis included 15 studies, which comprised a total of 1,124 patients, of which 701 had HGG and 423 had LGG. The pooled sensitivity and specificity of the studies overall were 0.92 (95% CI: 0.89-0.95) and 0.89 (95% CI: 0.85-0.92), respectively. The positive and negative likelihood ratios of the studies overall were 7.89 (95% CI: 6.01-10.37) and 0.09 (95% CI: 0.07-0.12), respectively. The pooled diagnostic odds ratio of the studies was 85.20 (95% CI: 54.52-133.14). The area under the summary receiver operating...
Source: Oncology Letters - Category: Cancer & Oncology Authors: Source Type: research