Accounting for fractionation and heterogeneous dose distributions in the modelling of osteoradionecrosis in oropharyngeal carcinoma treatment

CONCLUSION: Risk models for ORN based on conventional DVH parameters cannot be directly applied to HF-SBRT fractionation schemes and dose distributions. However, after correcting for fractionation and non-uniform dose distributions using EUD, a single model can distinguish between ORN and non-ORN after conventionally fractionated radiotherapy and hypofractionated boost treatments.PMID:37659662 | DOI:10.1016/j.radonc.2023.109889

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 2, 2023 Category: Radiology Authors: Gerda M Verduijn Nienke D Sijtsema Yvette van Norden Wilma D Heemsbergen Hetty Mast Aniel Sewnaik Denzel Chin Sarah Baker Marta E Capala Aad van der Lugt Esther van Meerten Mischa S Hoogeman Steven F Petit Source Type: research