New Allele-Specific Oligonucleotide (ASO) amplifications for Toxoplasma gondii rop18 allele typing: analysis of 86 human congenital infections in Brazil

In conclusion, all severe cases of congenital toxoplasmosis were infected during early pregnancy, but they were not exclusively associated with rop18 allele I parasites, as observed in murine toxoplasmosis. Furthermore, nearly one-fifth of parasites were non-archetypal, exhibiting more than one rop18 allele, indicating a higher genetic diversity of Toxoplasma gondii in this South American sample. Overall, a robust T. gondii rop18 allele typing was developed and suggested that congenital toxoplasmosis in humans involves complex mechanisms beyond the parasite genotype.PMID:37652181 | DOI:10.1016/j.actatropica.2023.107011

Source: Acta Tropica - August 31, 2023 Category: Infectious Diseases Authors: Emilly Henrique Dos Santos Gabriel Acca Barreira Lidia Yamamoto Mussya Cisotto Rocha Karen Alessandra Rodrigues Maria Carolina Pires Cruz Kelly Aparecida Kanunfre Thelma Suely Okay Source Type: research