Unleashing ferroptosis for cancer therapy with warfarin

Trends Endocrinol Metab. 2023 Aug 28:S1043-2760(23)00161-3. doi: 10.1016/j.tem.2023.08.008. Online ahead of print.ABSTRACTFerroptosis holds promise for cancer therapy. A recent study by Yang et al. in Cell Metabolism reveals that VKORC1L1-mediated reduction of vitamin K inhibits ferroptosis and establishes a direct p53-VKORC1L1 link in its regulation. As warfarin can inhibit VKORC1L1, the study further underscores this drug's potential as a cancer therapy.PMID:37648560 | DOI:10.1016/j.tem.2023.08.008

Source: Trends in Endocrinology and Metabolism: TEM - August 30, 2023 Category: Endocrinology Authors: Xiaoguang Liu Li Zhuang Boyi Gan Source Type: research