Genetic variants of phospholipase C- γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

Human genetic studies implicate PLCG2 variants in Alzheimer ’s disease risk, but the mechanism is unclear. Tsai et al. identify a PLCG2 loss-of-function variant that confers increased AD risk and demonstrate that gain- and loss-of-function PLCG2 AD variants uniquely alter microglial transcriptomes and direct plaque-responsive phenotypes, which may inform strategies to induce neuroprotective microglial responses to attenuate AD pathology.

Source: Immunity - September 1, 2023 Category: Allergy & Immunology Authors: Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Adrian L. Oblak, Gonzalo Viana Di Prisco, Nian Wang, Nicole Hajicek, Adam J. Carr, Emma K. Lendy, Oliver Hahn, Micaiah Atkins, Aulden G. Foltz, Jheel Patel, Guixiang Xu, Miguel Moutinho, John Sondek, Qish Tags: Article Source Type: research