Longitudinal transcriptomic analysis of human cortical spheroids identifies axonal dysregulation in the prenatal brain as a mediator of genetic risk for schizophrenia

Schizophrenia (SCZ) has a known neurodevelopmental etiology, but limited access to human prenatal brain tissue hampers the investigation of basic disease mechanisms in early brain development. Here, we elucidate the molecular mechanisms contributing to SCZ risk in a disease-relevant model of the prenatal human brain.

Source: Biological Psychiatry - September 1, 2023 Category: Psychiatry Authors: Ibrahim A. Akkouh, Thor Ueland, Attila Szabo, Timothy Hughes, Olav B. Smeland, Ole A. Andreassen, Jordi Requena Osete, Srdjan Djurovic Tags: Archival Report Source Type: research