Consensus document on acute-on-chronic liver failure (ACLF) established by the Mexican Association of Hepatology

Ann Hepatol. 2023 Jul 22:101140. doi: 10.1016/j.aohep.2023.101140. Online ahead of print.ABSTRACTAcute-on chronic liver failure (ACLF) has been an intensively debated topic mainly due to the lack of a unified definition and diagnostic criteria. The growing number of publications describing the mechanisms of ACLF development, the progression of the disease, outcomes and treatment has contributed to a better understanding of the disease, however, it has also sparked the debate about this condition. As an attempt to provide medical professionals with a more uniform definition that could be applied to our population, the first Mexican consensus was performed by a panel of experts in the area of hepatology in Mexico. We used the most relevant and impactful publications along with the clinical and research experience of the consensus participants. The consensus was led by 4 coordinators who provided the most relevant bibliography by doing an exhaustive search on the topic. The entire bibliography was made available to the members of the consensus for consultation at any time during the process and six working groups were formed to develop the following sections: 1.- Generalities, definitions, and criteria, 2.- Pathophysiology of cirrhosis, 3.- Genetics in ACLF, 4.- Clinical manifestations, 5.- Liver transplantation in ACLF, 6.- Other treatments.PMID:37482299 | DOI:10.1016/j.aohep.2023.101140

Source: Annals of Hepatology - July 23, 2023 Category: Gastroenterology Authors: Aldo Torre Laura Esthela Cisneros Garza Mauricio Castillo Barradas Nalu Navarro-Alvarez R Sandoval Salas Mar ía Sarai González Huezo Jos é Luís Pérez Hernández Osvely M éndez-Guerrero Jes ús Alejandro Ruiz Manríquez Rafael Trejo Estrada Norberto Source Type: research