SARS-CoV-2 mRNA vaccination induces an antigen-specific T cell response correlating with plasma interferon-gamma in B cell depleted patients
Emerging evidence is encouraging and suggests that a substantial proportion of patients without antibody responses (due to anti-CD20 therapy or other etiologies) to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines develop T cell responses. However, antigen-specific T cellular responses are notoriously difficult to assess clinically, given the lack of such assays under satisfactory CAP/CLIA regulation, and the laborious nature of the flow cytometric assessment. To evaluate the ability to apply a clinically feasible assay to measure T cellular responses to SARS-CoV-2 mRNA vaccination, we compared flow cytometric and enzyme-linked immunosorbent assay (ELISA) based assays in 24 participants treated with anti-CD20 therapy.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Tyler L. Borko, Ryan Baxter, Berenice Cabrera-Martinez, Eagappanath Thiruppathi, Maite Sabalza, Iswariya Venkataraman, Sean Selva, Cody Rester, Stefan Sillau, Daniel M. Pastula, Jeffrey L. Bennett, Enrique Alvarez, Robert Gross, Anna Shah, Ryan Kammeyer, Tags: Short Communication Source Type: research
More News: Allergy & Immunology | Brain | Coronavirus | Covid Vaccine | COVID-19 | Neurology | Respiratory Medicine | SARS | Vaccines