From Genetics to Therapy: Unraveling the Complexities of Richter Transformation in Chronic Lymphocytic Leukemia
With an estimated incidence of 4.7 new cases per 100,000 individuals, chronic lymphocytic leukemia (CLL) is the most common form of chronic leukemia in the USA and in Europe. [1] In 1928, Dr. Maurice N. Richter described a clinical case of a male diagnosed with CLL who developed constitutional symptoms. The enlarged lymph nodes found in the necropsy were diagnosed with a reticular cell sarcoma. [2] Since then, the occurrence of an aggressive lymphoma in patients with a previous or concurrent diagnosis of CLL has been termed Richter transformation (RT), a nosological entity recognized in the World Health Organization (WHO) and the International Consensus Classification (ICC).
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Pau Abrisqueta, Ferran Nadeu, Jan Bosch-Schips, Gloria Iacoboni, Angel Serna, Alba Cabirta, Lucrecia Y áñez, Leticia Quintanilla-Martínez, Francesc Bosch Tags: Anti-tumour Treatment Source Type: research
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