Computational Identification of Most Deleterious Missense Mutations in Human PD-1 Gene

In conclusion, the comprehensive screening process undertaken in this study has successfully identified R38C, D61V, R94C, and D117V as the primary mutations contributing to genetic cancer progression and immunotherapeutic resistance against PD-1 blockers. The integration of protein topology analysis, structural alignment, docking studies with PD-L1, and assessment of protein flexibility have collectively provided robust evidence to support the pathogenic significance of these mutations.PMID:37583448 | PMC:PMC10425257 | DOI:10.1155/2023/4360203
Source: The Scientific World Journal - Category: Science Authors: Source Type: research