Repeated chemogenetic activation of dopaminergic neurons induces reversible changes in baseline and amphetamine-induced behaviors

ConclusionsWe found that repeated DREADD activation of DA neurons evokes homeostatic changes that should be factored into the interpretation of chronic DREADD applications and their impact on circuit function and behavior. These effects are likely to also be seen in other neuronal systems and underscore the importance of studying neuroadaptive changes with chronic or repeated DREADD activation.

http://rd.springer.com/10.1007/s00213-023-06448-x

Source: Psychopharmacology - August 18, 2023 Category: Psychiatry Source Type: research