Successful In Situ Targeting of Pancreatic Tumors in a Novel Orthotopic Porcine Model Using Histotripsy

New therapeutic strategies and paradigms are direly needed to treat pancreatic cancer. The absence of a suitable pre-clinical animal model of pancreatic cancer is a major limitation to biomedical device and therapeutic development. Traditionally, pigs have proven to be ideal models, especially in the context of designing human-sized instruments, perfecting surgical techniques and optimizing clinical procedures for use in humans. However, pig studies have typically focused on healthy tissue assessments and are limited to general safety evaluations because of the inability to effectively model human tumors.

Source: Ultrasound in Medicine and Biology - August 16, 2023 Category: Radiology Authors: Khan Mohammad Imran, Jessica Gannon, Holly A. Morrison, Juselyn D. Tupik, Benjamin Tintera, Margaret A. Nagai-Singer, Hannah Ivester, Justin Markov Madanick, Alissa Hendricks-Wenger, Kyungjun Uh, David T. Luyimbazi, Michael Edwards, Sheryl Coutermarsh-Ott Tags: Original Contribution Source Type: research