GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid

CONCLUSIONS: MPO plus H2O2, and HOCl, impair coronary artery endothelium-dependent vasorelaxation via inhibition of NO. GYY4137 protects against endothelial dysfunction in arteries exposed to MPO plus H2O2, and HOCl. H2S donors such as GYY4137 are possible therapeutic options to control excessive MPO activity in cardiovascular diseases.PMID:37500030 | DOI:10.1016/j.vph.2023.107199

Source: Vascular Pharmacology - July 27, 2023 Category: Drugs & Pharmacology Authors: Andrew Harper Maike Chapel Grace Hodgson Krzysztof Malinowski Imogen Yates Michael Garle Vera Ralevic Source Type: research