Molecules, Vol. 28, Pages 6008: The Amoebicidal Activity of Diferrocenyl Derivatives: A Significant Dependence on the Electronic Environment

Molecules, Vol. 28, Pages 6008: The Amoebicidal Activity of Diferrocenyl Derivatives: A Significant Dependence on the Electronic Environment Molecules doi: 10.3390/molecules28166008 Authors: Yanis Toledano-Magaña Mario Néquiz Lucía Margarita Valenzuela-Salas Jessica J. Sánchez-García Rodrigo Galindo-Murillo Juan Carlos García-Ramos Elena I. Klimova Amoebiasis is the second leading cause of death worldwide associated with parasitic disease and is becoming a critical health problem in low-income countries, urging new treatment alternatives. One of the most promising strategies is enhancing the redox imbalance within these susceptible parasites related to their limited antioxidant defense system. Metal-based drugs represent a perfect option due to their extraordinary capacity to stabilize different oxidation states and adopt diverse geometries, allowing their interaction with several molecular targets. This work describes the amoebicidal activity of five 2-(Z-2,3-diferrocenylvinyl)-4X-4,5-dihydrooxazole derivatives (X = H (3a), Me (3b), iPr (3c), Ph (3d), and benzyl (3e)) on Entamoeba histolytica trophozoites and the physicochemical, experimental, and theoretical properties that can be used to describe the antiproliferative activity. The growth inhibition capacity of these organometallic compounds is strongly related to a fine balance between the compounds’ redox potential and hydrophilic character. The antiproliferative activity of diferr...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research