Philadelphia chromosome- positive myelodysplastic syndrome with single lineage dysplasia

Myelodysplastic syndrome (MDS) is a group of acquired clonal disorders characterized by dysplastic and ineffective hematopoiesis in the bone marrow. Various specific karyotypic and molecular abnormalities associated with MDS further guide the prognosis. Although translocation t(9;22)(q34;q11) (Philadelphia positive [Ph+]) and corresponding BCR-ABL fusion transcript are classically defined to differentiate CML from non-CML myeloproliferative disorders, it is also associated with adult acute lymphoblastic leukemia (Ph+ ALL), acute myeloid Leukemia (Ph+ AML), myelodysplastic syndrome (Ph+ MDS).

Source: Cancer Genetics and Cytogenetics - May 27, 2023 Category: Genetics & Stem Cells Authors: Ajeet Kumar, Vijai Tilak, Disha Arora, Marisha, Rahul, Deepak Gautam, Akhtar Ali Source Type: research