Myeloid Hif2 α is not essential to maintain systemic iron homeostasis.

Dietary consumption serves as the primary source of iron uptake, while erythropoiesis acts as a major regulator of systemic iron demand. In addition to intestinal iron absorption, macrophages play a crucial role in recycling iron from senescent red blood cells. The kidneys are responsible for the production of erythropoietin (Epo), which stimulates erythropoiesis, while the liver plays a central role in producing the iron-regulatory hormone hepcidin. The transcriptional regulator hypoxia-inducible factor (HIF)2 α has a central role in the regulation of Epo, hepcidin, and intestinal iron absorption and therefore plays a crucial role in coordinating the tissue crosstalk to maintain systemic iron demands.

Source: Experimental Hematology - August 8, 2023 Category: Hematology Authors: Chesta Jain, Sanjana Parmini, Wesley Huang, Sean Hannifin, Rashi Singhal, Nupur K. Das, Kyoung Eun Lee, Yatrik M. Shah Tags: Article Source Type: research