Early Life Exposure to Human Milk Oligosaccharides Reduces Allergic Response in a Murine Asthma Model

CONCLUSION: We propose a model in which orally administered HMOs delivered during early life shift the microbiota toward increased production of SCFAs, which dampens the allergic immune responses behind allergy and asthma. Overall, these data suggest the potential for HMO supplementation to protect infants against asthma development later in life, with possible benefits against additional atopic diseases such as eczema and food allergies.PMID:37545544 | PMC:PMC10404156 | DOI:10.1155/2023/9603576

Source: Journal of Immunology Research - August 7, 2023 Category: Allergy & Immunology Authors: Tahereh Bozorgmehr Rozlyn C T Boutin Sarah E Woodward Katherine Donald Jo May Chow Rachael H Buck B Brett Finlay Source Type: research