Atherosclerotic Disease: Pathogenesis and Approaches to Management

Med Clin North Am. 2023 Sep;107(5):793-805. doi: 10.1016/j.mcna.2023.04.004. Epub 2023 Jun 1.ABSTRACTAtherosclerotic disease, including stroke and myocardial infarction, is the leading cause of morbidity and mortality worldwide. Atherosclerotic plaque formation occurs in the setting of excess oxidative and hemodynamic stress and is perpetuated by smoking, poor diet, dyslipidemia, hypertension, and diabetes. Plaque may rupture, resulting in acute thrombotic events. Smoking cessation, lifestyle modification, risk factor optimization, and antithrombotic therapies are the mainstays of atherosclerotic disease management and are the cornerstones to reduce morbidity and mortality in this high-risk patient population. Novel therapeutics are in development and will add to the growing armamentarium available to physicians who manage atherosclerotic disease.PMID:37541708 | DOI:10.1016/j.mcna.2023.04.004

Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Amanda M Morrison Alexander E Sullivan Aaron W Aday Source Type: research