Evaluation of the cytotoxicity and genotoxicity of glufosinate-ammonium at technical and commercial grades in HepG2 cells
This study aimed to determine the cytotoxic and genotoxic effects of GLA on HepG2 cells. MTT and comet assays were performed to evaluate cell viability and DNA damage, respectively. HepG2 cells were exposed for 24 h to different concentrations of GLA (at 0.01 µg/mL; 0.04 µg/mL; 0.1 µg/mL; 0.24 µg/mL; 0.52 µg/mL; 1.25 µg/mL; 2.62 µg/mL and 13.12 µg/mL) in commercial- (Finale Ultra®) or technical-grade (GLAT). The results indicated that only Finale Ultra® induced a reduction in cell viability at 13.12 µg/mL. Furthermore, exposure to Finale Ultra® or GLAT was associated with increased DNA damage at concentrations from 0.52-13.12- µg/mL. This study shows the genotoxic effect of GLA on HepG2 cells.PMID:37516932 | DOI:10.1080/03601234.2023.2241322
Source: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes - Category: Environmental Health Authors: Ezeidy Denisse Gallardo-Valle Dayanne Carbajal-Nogueda Ma Elena Moreno-God ínez Eugenia Flores-Alfaro Isela Parra-Rojas Gerardo Huerta-Beristain Teresa Dom ínguez-Reyes Marco Antonio Ram írez-Vargas Source Type: research
More News: Cancer | Cancer & Oncology | Chemistry | Environmental Health | Science | Study | Toxicology