GYY4137, a hydrogen sulfide donor, protects against endothelial dysfunction in porcine coronary arteries exposed to myeloperoxidase and hypochlorous acid
CONCLUSIONS: MPO plus H2O2, and HOCl, impair coronary artery endothelial vasorelaxation via inhibition of NO. GYY4137 protects against endothelial dysfunction in arteries exposed to MPO plus H2O2, and HOCl. H2S donors such as GYY4137 are possible therapeutic options to control excessive MPO activity in cardiovascular diseases.PMID:37500030 | DOI:10.1016/j.vph.2023.107199
Source: Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Andrew Harper Maike Chapel Grace Hodgson Krzysztof Malinowski Imogen Yates Michael Garle Vera Ralevic Source Type: research