Equation-Based Low-Density Lipoprotein Cholesterol Reclassification and Implications For Lipid-Lowering Therapy

There are multiple guideline-endorsed equations for calculating low-density lipoprotein cholesterol (LDL-C). Initiating or intensifying lipid-lowering therapy (LLT) is recommended for adults above certain cut-points including an LDL-C greater than or equal to 190 mg/dL for adults without atherosclerotic cardiovascular disease (ASCVD) or greater than or equal to 70 mg/dL for adults with ASCVD.1 We determined the prevalence of adults whose need for LLT intensification would be reclassified based solely on whether the Martin-Hopkins or National Institutes of Health (NIH) –2 equation was used to calculate LDL-C compared with the traditionally used Friedewald equation.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Letters to the Editor Source Type: research