Plasma protein signatures reflect systemic immunity and allograft function in kidney transplantation

Kidney transplantation causes large perturbations of the immune system. While many studies focus on the allograft, insights into systemic effects are largely missing. Here, we analyzed the systemic immune response in three cohorts of kidney transplanted patients. Using serum proteomics, laboratory values, mass cytometry, histological and clinical parameters, inter-patient heterogeneity was leveraged for multi-omic co-variation analysis. We identified circulating immune modules (CIM) that describe extra-renal signatures of co-regulated plasma proteins.

Source: Translational Research - July 25, 2023 Category: Research Authors: Konrad Buscher, Rebecca Rixen, Paula Sch ütz, Birte Hüchtmann, Veerle van Marck, Barbara Heitplatz, Ulrich Jehn, Daniela A. Braun, Gert Gabriels, Hermann Pavenstädt, Stefan Reuter Source Type: research