Blood Flow ’s Effect on Percutaneous Absorption in Animal Models: A Systematic Review

AbstractIntroductionPercutaneous absorption is the deliverance of topically encountered molecules into the systemic circulation. This process can be harnessed therapeutically when prescribing topical medications, but is also the culprit of many toxicities. Many factors influence percutaneous absorption, an important yet understudied one being blood flow to the skin on which the chemical is applied.Purpose of ReviewThe aim of this work was to summarize the existing data investigating the relationship between blood flow and percutaneous absorption in animal models.MethodsPubMed and Embase databases were systematically searched and the data from eligible papers was analyzed. PRISMA guidelines were followed. Search words included “blood flow,” “circulation,” “percutaneous absorption,” “percutaneous penetration,” “dermal absorption,” and “dermal penetration.”Recent FindingsSix eligible articles were identified and analyzed. All studies utilized in vivo rat models and experimentally showed how absorption changed with different blood flow rates. All studies showed that the consequence of increased blood flow to the skin is an increase in the rate of delivery of molecules from the external environment into the bloodstream.SummaryClinicians should consider the importance of anatomical location and the density of local blood supply when prescribing transdermal medications. Additionally, first responders and researchers should be aware of how blood flow increases...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research