The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells

Enteric viruses can trigger loss of oral tolerance to dietary gluten, resulting in the development of celiac disease. Medina Sanchez et al. discovered Tritrichomonas arnold, a previously undescribed murine gut commensal protist capable of preventing virus-mediated loss of oral tolerance by directly restraining proinflammatory dendritic cell function.

https://www.cell.com/immunity/fulltext/S1074-7613(23)00279-0?rss=yes

Source: Immunity - July 20, 2023 Category: Allergy & Immunology Authors: Luzmariel Medina Sanchez, Magdalena Siller, Yanlin Zeng, Pamela H. Brigleb, Kishan A. Sangani, Ariadna S. Soto, Clarisse Engl, Colin R. Laughlin, Mohit Rana, Lauren Van Der Kraak, Surya P. Pandey, Mackenzie J. Bender, Britney Fitzgerald, Lee Hedden, Kay F Tags: Article Source Type: research