Calcitonin gene-related peptide inhibits neuronal apoptosis in heatstroke rats via PKA/p-CREB pathway

CONCLUSIONS: CGRP can protect against HS-induced neuron apoptosis via PKA/p-CREB pathway and reduce activation of caspase-3 by regulating Bcl-2. Thus CGRP may be a new target for the treatment of brain injury in HS.PMID:37423838 | DOI:10.1016/j.cjtee.2023.06.002

Source: Chinese Journal of Traumatology - July 9, 2023 Category: Orthopaedics Authors: Jie Zhu Ya-Hong Chen Jing-Jing Ji Cheng-Xiang Lu Zhi-Feng Liu Source Type: research