Choroid Plexus Calcification Correlates with Cortical Microglial Activation in Humans: A Multimodal PET, CT, MRI Study [FUNCTIONAL]

CONCLUSIONS: Choroid plexus calcification can be accurately and automatically quantified using low-dose CT and MRI. Choroid plexus calcification—but not choroid plexus volume—predicted cortical inflammation. Previously unmeasured choroid plexus calcium may explain recent reports of choroid plexus enlargement in human inflammatory and other diseases. Choroid plexus calcification may be a specific and relatively easily acquired biomarker for neuroinflammation and choroid plexus pathology in humans.

http://www.ajnr.org/cgi/content/abstract/44/7/776?rss=1

Source: American Journal of Neuroradiology - July 10, 2023 Category: Radiology Authors: Butler, T., Wang, X. H., Chiang, G. C., Li, Y., Zhou, L., Xi, K., Wickramasuriya, N., Tanzi, E., Spector, E., Ozsahin, I., Mao, X., Razlighi, Q. R., Fung, E. K., Dyke, J. P., Maloney, T., Gupta, A., Raj, A., Shungu, D. C., Mozley, P. D., Rusinek, H., Glod Tags: FUNCTIONAL Source Type: research