Increased TSPO expression, pyroglutamate-modified amyloid beta (A βN3(pE)) accumulation and transient clustering of microglia in the thalamus of Tg-SwDI mice

Epidemiological studies showed that Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) frequently co-occur; however, the precise mechanism is not well understood. A unique animal model (Tg-SwDI mice) was developed to investigate the early-onset and robust accumulation of both parenchymal and vascular A β in the brain. Tg-SwDI mice have been extensively used to study the mechanisms of cerebrovascular dysfunction, neuroinflammation, neurodegeneration, and cognitive decline observed in AD/CAA patients and to design biomarkers and therapeutic strategies.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research