Metabolomic Profile of Insulin Resistance Women with Systemic Lupus Erythematosus
Horm Metab Res 2023; 55: 487-492 DOI: 10.1055/a-2093-0260The aims of this study were in systemic lupus erythematosus (SLE) patients: 1) to
compare the metabolomic profile of insulin resistance (IR) with controls and 2)
to correlate the metabolomic profile with other IR surrogates and SLE disease
variables and vitamin levels. In this cross-sectional study, serum samples were
collected from women with SLE (n=64) and gender- and age-matched
controls (n=71), which were not diabetic. Serum metabolomic profiling
was performed using UPLC-MS-MS (Quantse score). HOMA and QUICKI were carried
out. Serum 25(OH)D concentrations were measured by chemiluminescent immunoassay.
In women with SLE, the metabolomic Quantose score significantly correlated with
HOMA-IR, HOMA2-IR, and QUICKI. Although concentrations of IR metabolites were
not different between SLE patients and controls, fasting plasma insulin levels
were higher and insulin sensitivity lower in SLE women. Interestingly, the
Quantose IR score was significantly correlated with complement C3 levels
(r=0.7; p=0.001). 25 (OH)D did not correlate with any metabolite
or the Quantose IR index. Quantose IR may be a useful tool for IR assessment.
There was a possible correlation between the metabolomic profile and complement
C3 levels. The implementation of this metabolic strategy may h...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Mungu ía-Realpozo, Pamela Mendoza-Pinto, Claudia Etchegaray-Morales, Ivet Osorio-Pe ña, Angel David V élez-Pelcastre, Sandra Escamilla-M árquez, Marco Antonio Ay ón-Aguilar, Jorge M éndez-Martínez, Socorro Garc ía-Carrasco, Mario Tags: Original Article: Endocrine Care Source Type: research