Treatment with sofosbuvir attenuates the adverse neurodevelopmental consequences of Zika virus infection in infant rhesus macaques

Zika virus (ZIKV) infection during infancy in a rhesus macaque (RM) model negatively impacts brain development resulting in long-term behavioral alterations. The current study investigated whether postexposure prophylaxis could alleviate these negative neurodevelopmental consequences. Three RM infants received a 14-day course of sofosbuvir (SOF; 15  mg/kg p.o.) treatment starting at 3 days post-infection with a Puerto Rican strain of ZIKV (PRVABC59) and were then monitored longitudinally for one year.

Source: Journal of Neuroimmunology - July 7, 2023 Category: Allergy & Immunology Authors: Alejandra Medina, Rebecca Rusnak, Rebecca Richardson, Matthew G. Zimmerman, Mehul Suthar, Nils Schoof, Zsofia Kovacs-Balint, Maud Mavigner, Mar Sanchez, Ann Chahroudi, Jessica Raper Source Type: research