Humanized CD36 mouse model supports the preclinical evaluation of therapeutic candidates targeting CD36

In this study, we have successfully generated a novel CD36 humanized mouse strain where the sequences encoding the extracellular domains of the mouse Cd36 gene were replaced with the corresponding human sequences. The results showed that CD36 humanized mice only expressed human CD36, and the proportion of each lymphocyte was not significantly changed compared with wild-type mice. Furthermore, CD36 monoclonal antibody could significantly inhibit tumor growth after treatment. Therefore, the CD36 humanized mice represent a validated preclinical mouse model for the evaluation of tumor immunotherapy targeting CD36.PMID:37407484 | DOI:10.1538/expanim.23-0021
Source: Experimental Animals - Category: Research Authors: Source Type: research