A mouse model of repeated traumatic brain injury-induced hearing impairment: Early cochlear neurodegeneration in the absence of hair cell loss

CONCLUSIONS: We conclude that rTBI results in chronic auditory dysfunction via damage to the spiral ganglion which occurs in the absence of any reduction in hair cell number. This suggests early neuronal damage that may be caused by systemic mechanisms similar to those leading to the spread of neuronal death in the brain following TBI. This TBI-hearing loss model provides an important first step towards identifying therapeutic targets to attenuate damage to the auditory system following head injury.PMID:37364367 | DOI:10.1016/j.heares.2023.108832

Source: Hearing Research - June 26, 2023 Category: Audiology Authors: Courtney Penn Karthick Mayilsamy Xiao Xia Zhu Mark A Bauer Shyam S Mohapatra Robert D Frisina Subhra Mohapatra Source Type: research