Viruses, Vol. 15, Pages 1488: Detection and Genetic Characterization of Astroviruses in Brain Tissues of Wild Raccoon Dogs

Viruses, Vol. 15, Pages 1488: Detection and Genetic Characterization of Astroviruses in Brain Tissues of Wild Raccoon Dogs Viruses doi: 10.3390/v15071488 Authors: Su-Beom Chae Chang-Gi Jeong Jun-Soo Park Eun-Jee Na Jae-Ku Oem Astroviruses (AstVs) have been detected in a wide range of animal species, including mammals and birds. Recently, a novel AstV associated with neurological symptoms has been detected in the brains of some mammals. Raccoon dog AstV has been reported recently in China. However, there have been no reports in South Korea. Therefore, the present study aimed to detect and genetically characterize AstVs in the intestine and brain tissues of 133 wild raccoon dogs collected in Korea between 2017 and 2019. Of the seven raccoon dogs, AstVs were detected in six intestinal tissues and four brain tissues. Analysis of the capsid protein amino acid sequences of raccoon dog AstVs detected in Korea revealed a high similarity to canine AstVs, suggesting possible interspecies transmission between raccoon dogs and dogs. Phylogenetic and capsid protein amino acid sequence analysis of raccoon dog AstVs detected in the brain the 17-148B strain belonging to the HMO clade and exhibiting conserved sequences found in neurotropic AstVs (NT-AstVs), indicating their potential as NT-AstVs. However, the pathogenicity and transmission routes of the raccoon dog AstV detected in Korea have not yet been elucidated, so further research and continued surveillance for AstV in w...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research