Randomized controlled phase IIa clinical trial of safety, pharmacokinetics and pharmacodynamics of tenofovir and tenofovir plus levonorgestrel releasing intravaginal rings used by women in Kenya

CONCLUSION: TFV/LNG and TFV-only IVRs were safe and well tolerated among Kenyan women. Pharmacokinetics and markers of protection against HIV-1, HSV-2, and unintended pregnancy suggest the potential for clinical efficacy of the multipurpose TFV/LNG IVR.CLINICAL TRIAL REGISTRATION: NCT03762382 [https://clinicaltrials.gov/ct2/show/NCT03762382].PMID:37383290 | PMC:PMC10293630 | DOI:10.3389/frph.2023.1118030

Source: Herpes - June 29, 2023 Category: Infectious Diseases Authors: Nelly R Mugo Victor Mudhune Renee Heffron Katherine K Thomas Eleanor McLellan-Lemal Betty Njoroge Sue Peacock Siobh án M O'Connor Beatrice Nyagol Eunice Ouma Renee Ridzon Jeffrey Wiener Nina Isoherranen David W Erikson Louise A Ouattara Nazita Yousefieh Source Type: research