Genomic profiling of metastatic castration-resistant prostate cancer samples resistant to androgen-receptor pathway inhibitors

CONCLUSIONS: Low AR activity, activation of stemness programs, and Hedgehog pathway were associated with primary ARPIs' resistance, whereas most acquired resistance was associated with subclonal evolution, AR-related events, and neuroendocrine differentiation.PMID:37364000 | DOI:10.1158/1078-0432.CCR-22-3736

Source: Cell Research - June 26, 2023 Category: Cytology Authors: Naoual Menssouri Loic Poiraudeau Carole Helissey Ludovic Bigot Jonathan Sabio Tony Ibrahim Cedric Pobel Claudio Nicotra Maud Ngo-Camus Ludovic Lacroix Etienne Rouleau Lambros Tselikas Anne Chauchereau F élix Blanc-Durand Alice Bernard-Tessier Anna Patrik Source Type: research