Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases

Arch Pharm Res. 2023 Jun 24. doi: 10.1007/s12272-023-01452-3. Online ahead of print.ABSTRACTCyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic microorganisms. cGAS/STING is positioned as a key axis of autoimmunity, the inflammatory response, and cancer progression, suggesting that the cGAS/STING signaling pathway represents an efficient therapeutic target. Based on the accumulated evidence, we present insights into the prevention and treatment of cGAS/STING-related chronic immune and inflammatory diseases. This review presents the current state of clinical and nonclinical development of modulators targeting cGAS/STING, providing useful information on the design of therapeutic strategies.PMID:37354378 | DOI:10.1007/s12272-023-01452-3
Source: Archives of Pharmacal Research - Category: Drugs & Pharmacology Authors: Source Type: research