The mechanism of LZ-8-mediated immune response in the mouse model of Parkinson's disease

Parkinson's disease (PD) is associated with microscopic changes in the brain, particularly substantia nigra (SN). Ganoderma lucidum immunoregulatory protein (rLZ-8) is might confer protective effects against PD.We developed a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced murine model of PD and determined the effects of rLZ-8 on molecular and cellular components of SN and whole brain tissue.The levels of SOD, GSH-Px, p-JAK2 and p-STAT3 in the brain tissue and SN were downregulated, while IL-6, IL-1 β, and TNF-α and MDA were upregulated.

Source: Journal of Neuroimmunology - June 26, 2023 Category: Allergy & Immunology Authors: Hong Cheng, Jingyu Wang, Yahui Zhang, Yingle Tang, Lin Zhu, Yan Tao, Wen Lu, Haifan Yang, Weiyi Zhu, Xin Tang, Xinran Qiao Source Type: research