Glomerular Filtration Rate Measurement and Chemotherapy Dosing

Many chemotherapeutic drugs used to treat malignancies undergo renal clearance. Thus, accurate knowledge of kidney function is critical to ensure proper dosing, maximize efficacy, and minimize toxicity of drugs that often have a narrow therapeutic index. Making this issue more salient is the fact that impaired kidney function, as assessed by glomerular filtration rate (GFR), is encountered commonly in patients with cancer. Recent data and expert guidelines recommend the use of the Chronic Kidney Disease –Epidemiology Collaboration equation to guide the assessment of kidney function, except when directly measured GFR is clinically necessary.

Source: Seminars in Nephrology - April 20, 2023 Category: Urology & Nephrology Authors: Mitchell H. Rosner, Ben Sprangers, Geeta Sandhu, Jolanta Malyszko Source Type: research