Human height: a model common complex trait

CONCLUSIONS: Given the similarity of height to other complex traits, the saturation of GWAS's ability to discover additional height-associated variants signals potential limitations to the omnigenic model of complex-phenotype inheritance, indicating the likely future power of polygenic scores and risk scores, and highlights the increasing need for large-scale variant-to-gene mapping efforts.PMID:37343163 | DOI:10.1080/03014460.2023.2215546

Source: Annals of Human Biology - June 21, 2023 Category: Biology Authors: Mitchell Conery Struan F A Grant Source Type: research