Sex-specific biobehavioral regulation of persistent inflammatory pain by alcohol

CONCLUSIONS: These data suggest that individuals may develop tolerance to alcohol's ability to alleviate both somatic and negative motivational symptoms of chronic pain over time. We also discovered sex-specific neuroadaptations in protein kinase A (PKA)-dependent phosphorylation of GluR1 subunits and extracellular signal-regulated kinase (ERK 1/2) phosphorylation in nociceptive brain centers of animals receiving an alcohol challenge 1 week post-CFA. Together these findings illustrate a sex-specific regulation of behavioral and neurobiological indices of persistent pain by alcohol.PMID:37208939 | DOI:10.1111/acer.15104
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Source Type: research