Impact of aluminum adjuvants on the stability of pneumococcal polysaccharide-protein conjugate vaccines

This study suggests a formulation, which includes AAHS, may negatively impact the stability of a pneumococcal polysaccharide-protein conjugate vaccine that contains phosphodiester groups. This decrease in stability would likely result in a decrease in the "active" concentration of antigen dose, and herein, it is shown that such instability directly compromised vaccine immunogenicity in an animal model. The results presented in this study help to explain critical degradation mechanisms of pneumococcal polysaccharide-protein conjugate vaccines.PMID:37321893 | DOI:10.1016/j.vaccine.2023.05.059

Source: Vaccine - June 15, 2023 Category: Allergy & Immunology Authors: William J Smith Rachel Thompson Patricia M Egan Yuhua Zhang Lani Indrawati Julie M Skinner Jeffrey T Blue Michael A Winters Source Type: research