Ythdf2 regulates cardiac remodeling through its mRNA target transcripts

m6A mRNA methylation controls cardiomyocyte function and increased overall m6A levels are a stereotyping finding in heart failure independent of the underlying etiology. However, it is largely unknown how the information is read by m6A reader proteins in heart failure. Here we show that the m6A reader protein Ythdf2 controls cardiac function and identified a novel mechanism how reader proteins control gene expression and cardiac function. Deletion of Ythdf2 in cardiomyocytes in vivo leads to mild cardiac hypertrophy, reduced heart function, and increased fibrosis during pressure overload as well as during aging.

Source: Journal of Molecular and Cellular Cardiology - June 11, 2023 Category: Cytology Authors: V. Kmietczyk, J. Oelschl äger, P. Gupta, E. Varma, S. Hartl, J. Furkel, M. Konstandin, A. Marx, Z. Loewenthal, V. Kamuf-Schenk, L. Jürgensen, C. Stroh, A. Gorska, A. Martin-Garrido, J. Heineke, T. Jakobi, N. Frey, M. Völkers Source Type: research