Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway

Conclusion: Together, these data reveal the unprecedented endothelial cofilin-1/PP2AC signaling axis downstream of metformin in protecting against lung vascular endothelial injury and inflammation. Therefore, pharmacologically enhancing endothelial PP2AC activity may lead to the development of novel therapeutic approaches for prevention of deleterious effects of ALI on vascular ECs.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research