Study protocol to assess the quality of life after preventive bilateral salpingo-oophorectomy in BRCA1/2 and PALB2 mutation carriers

Introduction: Pathogenic variants in BRCA1, BRCA2 and PALB2 genes are associated with a high lifetime breast cancer (BC) and a high or moderate ovarian cancer (OC) risk, respectively. Preventive bilateral salpingo-oophorectomy (PBSO) is a mortality reducing strategy recommended to healthy carriers at the age of 35 –40 or after completion of childbearing. The main reason for delaying surgery is women´s fear of the impact of premature menopause on quality of life and long-term health risks.

Source: Maturitas - June 8, 2023 Category: Primary Care Authors: Patricia Muro Blanc, Nuria Calvo Verges, Rosa Alfonso Ruiz, Javier Gavira Diaz, Josep Perell ó Capó, Cristina Soler Moreno, Ramon Rovira Negre, Teresa Ramon y Cajal Asensio, Misericordia Guinot Gasull Tags: Abstract ID: 223 Source Type: research