Genetic Factors Influencing Warfarin Dose in Han Chinese Population: A Systematic Review and Meta-Analysis of Cohort Studies

ConclusionThis is the first systematic review and meta-analysis assessing the association between single nucleotide polymorphisms (SNPs) of various genes known to influence MDWD besidesCYP2C9 andVKORC1 in the Han Chinese population.CYP4F2 (rs2108622),GGCX (rs12714145),EPHX1 (rs2292566 and rs2260863),ABCB1 (rs2032582),NQO1 (rs1800566), andCALU (rs2290228) SNPs might be moderate factors affecting MDWD requirements.Registered informationPROSPERO International Prospective Register of Systematic Reviews (CRD42022355130).
Source: Clinical Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research